Li-Sheng Zhang, Kang Chen, Guihua Chen
Jan 4, 2013
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Organic letters
Abstract
The first palladium-catalyzed ortho-trifluoromethylation of the aromatic C-H bond directed by an acetamino group is reported. This method provides an efficient and green approach to synthesize the highly biological potential key structure of ortho-CF(3) acetanilides and anilines.