L. Chao-pin
2009
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Journal
Progress in Veterinary Medicine
Abstract
Animal blood resource is rich in our country.Heme was extracted from animal blood,then protoporphyrin disodium(NAPP) was prepared from the heme through the intermediates of protoporphyrin-dimethyleser and so on.Organic solvent extraction,column chromatography,chromatographic analysis and high performance liquid chromatogram are used to separate and purify porphyrin compounds as four main methods at present.NAPP is a kind of water-soluble sodium salt with hepatoprotective and reducing transaminase effects and curently used to restore hepatic function of liver damage patients as a kind of improving agents of liver functions in clinical.In recent years,some scholars also preliminarily studied the anti-hepatitis virus activity and mechanism of NAPP and found that NAPP have anti-hepatitis B and C virus effects in vivo and vitro.It is thus clear that using animal blood to prepare NAPP has vital significance for utilizing our abundant animal blood resources and promoting the research and development of biochemical drugs.This article reviewed the preparation methods,separation and purification methods,usage,pharmacological actions and activities of NAPP.