Zhou Kai
2010
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Journal
Journal of Wuhan Institute of Technology
Abstract
4-(4-Fluorophenyl)-2-(2-methylpropanoyl)-4-oxo-N,β-diphenylbutanamide is a key intermediate of atorvastatin.Methyl isobutyryl acetate was transformed into 4-methyl-3-oxo-N-pentanamide by reaction with aniline;the resulting product could undergo Knoevenagel condensation with benzaldehyde giving 4-mehtyl-3-oxo-N-Phenyl-2-(Phenylmethylene)Pentanamide,which could further undergo Stetter reation with p-fluorobenzaldehyde thus giving aceess to the final molecule 4-(4-Fluorophenyl)-2(2-methylpropanoyl)-4-oxo-N,β-diphenylbutanamide.The synthetic route were easily available and the yield was reasonable.The structures of the main intermediates were identified by 1H NMR.