Wang Xiao-meng
2010
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Quality indicators
Journal
Journal of Hainan Medical University
Abstract
Objective:To investigate the allergia,haemolyticus and vascular irritation of pefloxacin mesylate injection for the sake of safe clinical administration.Methods:Active systemic allergic guinea pig test(ASA) and the rat passive cutaneous anaphylaxis test(PCA) were used as sensitization testing;haemolyticus was determined by conventional haemolytic in vitro test tube method and irritation by comparing left and right side of body.Results:Pefloxacin mesylate injection showed negative results in both active systemic allergic test on guinea pig and passive cutaneous anaphylaxis test on rat.No hemolysis of rabbit red blood cells and the agglutination reaction were observed.And intravenous drip showed no obvious irritation.Conclusions:The pefloxacin mesylate injection meet the security requirement for clinical administration.