F. Ludueña, J. O. Hoppe, I. H. Oyen
Apr 1, 1958
Citations
0
Influential Citations
6
Citations
Journal
Journal of Dental Research
Abstract
M ANY investigators have studied one or more of the pharmacologic properties of racemic nordefrin* (2,4-dihydroxy-phenyl-3-hydroxy-2-isopropylamine) but much less is known about the differences in activity between the levo-t and dextro-isomers. Schaumann' has reported on the toxicity of levoand dextro-nordefrin and their effect on the blood pressure of dogs and cats and the blood sugar and uterus of rabbits. Studies in this laboratory2' 3 have shown that the activity ratios of the optical isomers of isoproterenol and hyoseyamine were much larger than those indicated in the literature. These higher ratios were the result of a higher degree of purity of the dextro compounds. In view of these results, it was decided to study some of the pharmacologic properties of levoand dextronordefrin, especially their relative activity. The resolution of nordefrin and the purification of the isomers by repeated crystallizations have been carried out and the results obtained with these samples on the perfused guinea pig lung have been reported recently.4