N. Baidya, M. Olmstead, P. Mascharak
Oct 1, 1991
Citations
0
Influential Citations
27
Citations
Journal
Inorganic Chemistry
Abstract
For some time D-penicillamine (D-H[sub 2]Pen) has been in use for removing excess copper from patients with Wilson's disease. In recent years, D-H[sub 2]Pen has also afforded promising results in the treatment of acute intoxidation with other metals, especially nickel. The authors report here the structure and spectral parameters of a genuine [NiL[sub 2]][sup 2[minus]] complex of D-H[sub 2]Pen formed under the condition of excess drug (therapeutic level). In addition, the structural features of this complex, namely potassium bis(D-penicillaminato-N,S)nickelate(II) tetrahydrate (1) are compared with those of potassium bis(L-cysteinato-N,S)nickelate(II) sesquihydrate (2), recently reported by this group. Since (a) solution studies by them as well as other groups have demonstrated the existence of only the [NiL[sub 2]][sup 2[minus]] species and (b) the complex 1 is extremely stable in aqueous and saline solutions in the pH range 6-10, it is quite possible that excess nickel is excreted from the body in this form.