I. Rosenblum, A. Wohl, A. Stein
Mar 1, 1965
Citations
0
Influential Citations
20
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract The effects on plasma nonesterified fatty acids (NEFA) and glucose of five sympathomimetic amines were investigated in order to determine the importance of these metabolic effects in the etiology of cardiac lesions as induced by these amines. Of these five, isoproterenol, nordefrin, and norepinephrine caused significant elevations in both plasma total NEFA and glucose. Methoxamine caused a significant reduction in plasma NEFA while elevating plasma glucose, and ephedrine produced no significant changes in the plasma levels of either NEFA or glucose. It is proposed that amines which cause a marked elevation in plasma NEFA also cause an accumulation of lipids in the myocardium. Accumulation of these lipids, which are esters of fatty acids, can lead to the development of cardiac lesions through an ultimate mechanism which is still unknown. Because cardiac lesions can be produced also by amines which have no significant effects on either plasma NEFA or glucose, the etiology of these lesions must have more than a single mechanism.