Shirui Mao, Lei Wang, Cuifang Cai
2002
Citations
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Influential Citations
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Citations
Quality indicators
Journal
Journal of Shenyang Pharmaceutical University
Abstract
Objective The study is to use the hydrosoluble pefloxacin mesylate was used as a model drug to study the effects of hydrogel kinds, concentration and penetrating accelerant on drug release mechanism. Methods Semi permeable membrane diffusion and in vitro skin diffusion, were used to evaluate drug release characteristics, and more, the cumulative release amount and permeability coefficients were calculated. Results The in vitro release of pefloxacin mesylate from sodium alginate, CMC Na, MC, xanthum gum, HPMC followed. The Higuchi equation, respectively, and followed the zero order equation across the rat′s skin. By using CMC Na as the matrix, it was indicated that the propylene glycol and azone were all sorbefacient, the penetrating effect of azone was more evident; but when they were used together, antagonism appeared. Conclusions The results of our study showed that different kinds and different concentrations of hydrogel had different release rates; different research methods resulted in different release mechanisms; there was no correlation between the drug concentration and penetration coefficient; the addition of propylene glycol and azone could facilitate transdermal absorption.