L. Bunalema, M. Ocan, Bbosa S. Godfrey
2022
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Journal
SSRN Electronic Journal
Abstract
Anti-Mycobacterial and Synergistic Activity of Synthetic Acridine-9-Carboraldehyde and 9-Hydroxy-4-Methoxy Acridine Alkaloids against Clinical Isolates of Multidrug-Resistant Abstract Background : Tuberculosis treatment has become difficult due to development of strains that are resistant to both first and second-line anti-TB drugs. This calls for a continued development of new drugs with novel targets against multi and extensively drug-resistant strains of M . tuberculosis . The aims of the study were; i) to determine the antimycobacterial activity of two synthetic alkaloids i.e., dehyde and 9-hydroxy-4-methoxy acridine as well as their interactions with conventional anti-TB drugs ie isoniazid, rifampicin and ciprofloxacin. Results: Acridine-9-carboraldehyde was active on both susceptible and multidrug-resistant strains of TB with minimum inhibitory concentrations of 0.238µg/mL and 0.108 µg/mL on the pan-sensitive and clinical susceptible strains and 0.157 µg/mL and 0.196 µg/mL on the rifampicin resistant and multidrug-resistant strains respectively. In addition, acridine-9-carboraldehyde was synergistic to both rifampicin and levofloxacin with a fractional inhibitory concentration index of ≤ 0.5. Conclusion: Acridine-9-carboraldehyde is active against clinical isolates of multidrug-resistant M. t uberculosis. And it is synergistic with rifampicin and levofloxacin on susceptible and multidrug-resistant M . tuberculosis