K. Iida, Y. Nakajima, M. Kajiwara
May 1, 2008
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Journal
Current Radiopharmaceuticals
Abstract
1-Amino-2-[3-13C]propanol hydrochloride (1) was synthesized by the coupling reaction of 2-phthalimidoacetyl chloride (2) with [13C]methylmagnesium iodide in the presence of copper iodide, followed by reduction with sodium borohydride and hydrolysis, in 64 % total yield from the 13C-source. All 13C- and 15N-isotopomers of 1-amino-2-propanol are now obtainable by using appropriate combinations of 13C-labeled sodium acetate, 13C- and/or 15N-labeled glycine, and potassium [15N]phthalimide.