M. R. Harnden, R. L. Jarvest, M. J. Parratt
1992
Citations
0
Influential Citations
11
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
Pyrrolidin-1-yl derivatives of pyrimidines and purines, incorporating the phosphonomethoxy group as a phosphate mimic, were prepared as analogues of 2′,3′-dideoxynucleotides. The heterocyclic bases uracil, thymine, cytosine, adenine and hypoxanthine were constructed upon the primary amino group of the N-aminopyrrolidine 7, which was prepared by reaction of the dibromide 6 with hydrazine.