M. Maeda, Y. Tatsuki, T. Fukumura
May 1, 1989
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0
Influential Citations
2
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
5-Fluoromethyl-, 5-(2′-fluoroethyl)- and 5-(3′-fluoropropyl)-5-methyloxazolidine-2,4-diones (4a,b,c) were prepared as potential indicators of tissue pH, based on the fluorinative dehydroxylation with diethylaminosulfur trifluoride and/or the displacement reaction with fluoride ion. 5-(3′-[18F]Fluoropropyl)-5-methyloxazolidine-2,4-dione (4d) was obtained by tosylate displacement in 14-16% radiochemical yield in a synthesis time of 40 min from start of the radiofluorination. The other two congeners labeled with 18F resisted our efforts to prepare them using [18F]fluoride ion.