F. Yin, A. Garifullina, F. Tanaka
Jul 26, 2017
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Influential Citations
3
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Journal
Organic & biomolecular chemistry
Abstract
To concisely synthesize highly enantiomerically enriched 5-alkyl-substituted pyrrolidine-3-carboxylic acids, organocatalytic enantioselective Michael addition reactions of 4-alkyl-substituted 4-oxo-2-enoates with nitroalkanes have been developed. Using the developed reaction method, 5-methylpyrrolidine-3-carboxylic acid with 97% ee was obtained in two steps.