Chu De-qing
2011
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
A key medicine intermedia,N-(2′-chloropyrimidin-4′-yl)-N,2,3-trimethyl-2H-indazol-6-amine(5),was obtained by N-methylation,catalytic reduction,nucleophilic substitution and alkylated reaction from 3-methyl-6-nitro-1H-indazole.Eleven novel N-(2′-arylaminepyrimidin-4′-yl)-N,2,3-trimethyl-2H-indazol-6-amine derivatives were synthesized by nucleophilic substitution of 5 with arylamine.The structures were characterized by 1H NMR and EI-MS.The preliminary bioassay test indicates that some of them exhibited obvious antitumor activities.