Wael S. I. Abou-Elmagd, A. Hashem
2016
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0
Influential Citations
20
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
2(3H)-furanone 1 was fused with methyl-4-aminobenzoate followed by hydrazinolysis to give the acid hydrazide derivative 3. Treatment of 3 with carbon disulfide gave 4-amino-5-mercapto-3-substituted triazole derivative 5. The presence of mercapto and amino groups adjacent to each other in compound 5 made it valuable key precursor for the formation of fused and spiro heterocycles. Ring transformation of 5 into triazolothiadiazole and triazolothiadiazine derivatives is investigated. The antitumor and antimicrobial activities of the synthesized compounds were evaluated. Some of the tested compounds showed promising activities.