Yanfang Zhao, Zijian Liu, X. Zhai
May 1, 2013
Citations
0
Influential Citations
12
Citations
Quality indicators
Journal
Chinese Chemical Letters
Abstract
Abstract A series of novel diaryl ureas containing 4-[(2-amino-6-trifluromethyl)pyrimidine-4-yl]piperazine-1-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib, some compounds showed more potent and a broader spectrum of anti-cancer activities. Among them, compound 2p demonstrated significant inhibitory activities against MDA-MB-231, HT-29 and MCF-7 cell lines with IC 50 values of 0.016, 0.63, 0.001 μmol/L, respectively.