I. H. E. Azab, M. Aly, A. Gobouri
2017
Citations
0
Influential Citations
13
Citations
Journal
Heterocycles
Abstract
A novel series of 9-substituted-chromeno[4',3':3,4]pyrrolo[2,1-c][1,2,4]triazole-6,7-diones (4), chromeno[4',3':3,4]pyrrolo[1,2-d]tetrazole-6,7-dione (5), 9-phenyl-6Hchromeno[4',3':3,4]pyrrolo[2,1-c][1,2,4]triazine-6,7(11H)-dione (8), chromeno[4',3':3,4]pyrrolo[2,1-c][1,2,4]triazole-6,7,9(10H)-trione (10), (3,5-substituted-pyrazol-1-yl)chromeno[3,4-c]pyrrole-3,4-dione (15-19) and thiazole derivatives (28-37) were synthesized using 1-hydrazinylchromeno[3,4-c]pyrrole-3,4-dione (2) as a precursor. The newly synthesized compounds were characterized and evaluated for their cytotoxic activity. INTRODUCTION Various natural and synthetic biologically active compounds are found to be nitrogen containing heterocycles and have attracted continuing interest of the researchers in the past few decades due to their diverse therapeutic values.1-4 Among diverse classes of antimicrobial agents, azoles have very good anti-bacterial properties and nitroimidazoles are the most known among them. Other azoles such as triazole,5, 6 benzimidazole,7-10 and pyrazole11 are potent anti-bacterial agents. Triazoles, in particular 1,2,4-triazole nucleus have been inserted into a wide variety of therapeutically interesting drug candidates including anti-inflammatory drugs, CNS stimulants, anxiolytic, sedatives, 1456 HETEROCYCLES, Vol. 94, No. 8, 2017