Zhou Xi
2015
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Journal
Chemical Reagents
Abstract
There have been some reports on the bactericidal activity of fluorine-containing compounds. This work has introduced fluorine inthieno[2,3-d]pyrimidin-4( 3H)-one,to determine its bactericidal activity. Relevant materials have been used to produce thieno through Gewald reaction and then with which reacts PPh3,C2Cl6,Et3 N to produce iminophosphorane,then react with4-fluorophenyl ssocyanate and primary amine to produce some new materials: 2-alkylamino-3-( 4-fluorophenyl)-5-methyl-6-( 1H-1,2,4-triazol-1-yl)-thieno [2,3-d]pyrimidin-4( 3H)-ones. The structures were confirmed by1 HNMR,MS and elemental analysis. The biological activity tests showed that some of them exhibited a strong inhibiting effect upon crop biomasses and 2-( n-heptyl) amino-3-( 4-fluorophenyl)-5-methyl-6-( 1H-1,2,4-triazol-1-yl)-thieno[2,3-d]pyrimidin-4( 3H)-one provided 90% inhibition activity against cotton fusarium wilt. The bactericidal activity of those materials has a certain increased against some not containing fluorine elements of thieno[2,3-d]pyrimidin-4( 3H)-ones.