Catarina A. B. Rodrigues, J. Martinho, C. Afonso
Jul 29, 2015
Citations
1
Influential Citations
17
Citations
Journal
Journal of Chemical Education
Abstract
The synthesis of (Z)-4-(4-nitrobenzylidene)-2-phenyloxazol-5(4H)-one, which is a potent immunomodulator and tyrosinase inhibitor, is described as an experiment for an upper-division undergraduate organic chemistry laboratory course. This compound is produced via an Erlenmeyer–Plochl reaction in the absence of any additional solvents and is isolated without need of preparative chromatography, yielding up to 97% of product.