X. Qian, B. Zheng, Brian Burke
Apr 27, 2002
Citations
1
Influential Citations
31
Citations
Journal
The Journal of organic chemistry
Abstract
A highly stereoselective synthesis of the novel tryptase inhibitor BMS-262084 was developed. Key to this synthesis was the discovery and development of a highly diastereoselective demethoxycarbonylation of diester 12 to form the trans-azetidinone 13. BMS-262084 was prepared in 10 steps from D-ornithine in 30% overall yield.