Gu Rui-xia
2011
Citations
0
Influential Citations
0
Citations
Journal
Journal of Hebei Normal University
Abstract
Abafungin(1) was obtained by condensation N-(1,4,5,6-tetrahydropyrimidinyl)thiourea(3) and α-chloro-2-(2,4-dimethylphenoxy)acetophenone(5).Starting from dimethyl cyanoimidodithiocarbonate and 1,3-propanediamine via cyclization,then addition with H2S,compound 3 was prepared.Meanwhile,by Ullmann reaction and carbonyl α-chlorination with 2,4-dimethylphenol and 2-bromoacetophenone as raw material,compound 5 was also given.The total yield of abafungin was up to 58.3 %(calculated on the basis of 2-chloroacetophenone).The structures of the final product and intermediates were confirmed by 1HNMR,13CNMR,elemental analysis and other methods.