Zhan Feilong
2011
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
N-(2-Butylbenzofuran-5-yl) acetamide and 4-(3-chloropropoxy) benzoyl chloride underwent Friedel-Crafts reaction and condensation with dibutylamine to get N-[2-butyl-3-[4-(3-chloropropoxy) benzoyl]benzofuran- 5-yl]acetamide(5),followed by hydrolysis with hydrochloric acid,salification with oxalic acid to give(5-amino-2-butylbenzofuran -3-yl)[[4-(3-(dibutylamino)propoxy]phenyl]methanone oxalate,the latter was converted to dronedarone hydrochloride by sulfonation with methanesulfonyl chloride and salification.The overall yield was about 41%.