Li Ming-zhu
2012
Citations
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Influential Citations
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Citations
Quality indicators
Journal
Journal of Medical Science Yanbian University
Abstract
OBJECTIVE To synthesize the 2-(4-(4-benzyl-substituted) piperazin-1-yl) ethyl 2-(1-(pyridin-2-yl) ethoxy) acetates,and to study the its effects on learning and memory facilitation in mice.METHODS The 2-(1-bromoethyl) pynidine(2) was obtained through Whol-ziegler reaction by using 2-ethylpyridine(1) as the starting material,and the compound 2 was reacted with sodium 2-ethoxy-2-oxo-ethanolate to give ethyl [2-(1-(pyridine-2-yl)ethoxy)] acetate(3).The compounds 4a-4l were obtained by the reaction of piperazine anhydrous with different benzyl chlorides,and the compounds 4a-4l and bromoethanol were used to synthesize compounds 5a-5l,and they were further reacted with compound 3 to obtain compounds 6a-6l,respectively.The effects of compound 6j on learning and memory in mice were tested by using water maze test.RESULTS Twelve new compounds were designed and synthesized,and the structures of compounds were confirmed by IR,1H-NMR and MS spectrum.As compared with the model control group,the arriving times significantly shortened,and the numbers of errors obviously diminished in large and small doses of compound 6j groups(P0.05).CONCLUSION The pharmacological results showed that compound 6j has strong learning and memory facilitation in mice.