Shen Dong-sheng
2005
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Ethyl 2-(4-bromomethylphenyl)propionate,key intermediate of Loxoprofen,was synthesized from toluene via Friedel-Crafts reaction and bromination.The structure was determined by(~1H NMR,) IR and MS.The optimal reaction conditions of synthesizing 2 were as follow: the temperature was 35 ℃;the catalyst was 50.0 g;the reaction time was 6 h;the volume of toluene was(104.0) mL;the initiator of the bromination was benzoperoxide.The total yield was 70%.