A. Bekhit, N. S. Habib, A. El-Din
Sep 1, 2001
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Influential Citations
21
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Journal
Bollettino chimico farmaceutico
Abstract
The increasing clinical importance of drug-resistant bacterial pathogens has encouraged additional microbiological and antibacterial research. New chalcone and sydnone derivatives of 4(3H)-quinazolinone were synthesized and evaluated for their antibacterial and antifungal activity. The microorganisms used were Escherichia coli ATCC 25922 as Gram-negative bacteria, Staphylococcus aureus ATCC 19433 as Gram-Positive bacteria and Candida albicans as yeast like fungi. The most potent compound was the nitroso derivative 6b, which exhibits interesting antibacterial and antifungal activities.