He Yong-jun
2007
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Journal
The Chinese Journal of Modern Applied Pharmacy
Abstract
OBJECTIVE To synthesize Ioxitalamic acid,a ionic x-ray contrast agent.METHODS Ioxitalamic acid was synthesized by steps of esterification,amidation,reduction,iodization and acetylation from 5-nitro-isophthalic acid.RESULTS The chemical structure of the synthesized product were confirmed by element analysis,1H-NMR,13C-NMR,MS(FAB).CONCLUSION The process can be easily controlled and is suitable for a scale production.