R. Jasztold-Howorko, M. Pełczyńska, A. Nasulewicz
Nov 1, 2005
Citations
0
Influential Citations
13
Citations
Journal
Archiv der Pharmazie
Abstract
Starting from 2‐(6‐methoxy‐1‐methyl‐9H‐carbazol‐2‐yl)ethylamine 7 and mixed anhydrides of 4‐nitrobenzoic acid or 4‐methoxybenzoic acid, the corresponding 5,6‐dimethyl‐9‐methoxy‐1‐(4‐substituted phenyl)‐6H‐pyrido[4,3‐b]carbazoles 11a–b, 5,6‐dimethyl‐9‐hydroxy‐1‐(4‐substituted phenyl)‐6H‐pyrido[4,3‐b]carbazoles 12a, 12c, and their quaternary salts 13a–d were obtained. The four new pyridocarbazole derivatives 12a–c and 13d satisfy the international activity criterion for synthetic compounds, namely an ID50 value lower then 4 μg/mL in preliminary in vitro cytotoxic activity screening against the A549 cell line (non‐small cell lung cancer).