Zhang Rong-ming
2008
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Journal
Chemistry & Bioengineering
Abstract
Lauric acid-2-hydroxy-3-propane sulfonic acid sodium salt was synthesized by using sodium bisulfite,epichlorohydrin,sodium phosphate and lauric acid as raw materials.The influential factors,such as reaction temperature,reaction time,the amount of catalyst and reactant molar ratio were explored.The optimum method for synthesizing the objective compound was determined as follows:the molar ratio of sodium bisulfite to epichlorohydrin was 1.15∶1,firstly,epichlorohydrin solution was dropped into sodium bisulfite sloution for 2 h and reacted for 1.5 h at 85℃ to obtain 3-chloro-2-hydroxy-propane sulfonic acid sodium;secondly,3-chloro-2-hydroxy-propane sulfonic acid sodium was dropped into sodium phosphate solution and reacted for 4 h at 55℃ to obtain 2,3-oxiranemethane sulfonic acid sodium salt;finally,2,3-oxiranemethane sulfonic acid sodium salt was dropped into lauric acid solution for 0.5 h and reacted for 2.5 h at 90℃ to obtain lauric acid-2-hydroxy-3-propane sulfonic acid sodium salt.The highest yield reached 85.2%.And the product was characterized by FTIR.