Zhao Hong-liang
2009
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Journal
Chemistry World
Abstract
Starting from 2-chlorobenzyl alcohol and bis(trichloromethyl) carbonate,2-chlorobenzyl chloroformate was synthesized with dichloroethane as the solvent,then via reaction with N-hydro-xysuccinimide,the important peptide protecting reagent,N-(2-chlorobenzyloxycarbonyloxy)-succinimide was successfully obtained.The optimum reaction conditions of the two steps were found and the total yield reached 50%.The product was confirmed by()~1H NMR.