A. A. Hameed, E. K. Ahmed, A. A. A. fattah
Apr 3, 2017
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0
Influential Citations
12
Citations
Journal
Research on Chemical Intermediates
Abstract
A convenient, simple and efficient synthesis of polyfunctionally substituted cinnolines has been developed that involves the reaction of ethyl 5-cyano-4-methyl-1-aryl-6-oxo-1,6-dihydropyridazine-3-carboxylate with nitroolefins in dioxane/piperidine under controlled microwave irradiation. The obtained heterocycles are a privileged scaffold in a few natural compounds and in many drugs with a broad spectrum of biological activities.Graphical Abstract