I. Ueda, K. Ishii, K. Shinozaki
Nov 25, 1990
Citations
0
Influential Citations
4
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
N-Phenoxypropylacetamide derivatives were prepared and tested for antiulcer activity. These compounds exhibited both gastric acid antisecretory and cytoprotective properties. Structure-activity studies led to the identification of N-[3-(3-(1-piperidinylmethyl)phenoxy)propyl]-2-(2-hydroxyethylt hio)acetamide (8), which was selected for further development and clinical evaluation.