I. Ekhato, S. Bonacorsi
Apr 1, 2011
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Influential Citations
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Irbesartan (Avapro™) is in clinical use as an antihypertensive drug. It is a nonpeptide angiotensin II receptor antagonist. A radiolabeled version of this drug, intended for use in environmental fate studies, was prepared from N,N-dimethyl[14C]formamide. Our method of synthesis gave 18% overall yield and a radiochemical purity of 98.22%. Copyright © 2010 John Wiley & Sons, Ltd.