T. Perry, S. Hansen, D. Love
Aug 31, 1968
Citations
2
Influential Citations
68
Citations
Quality indicators
Journal
Lancet
Abstract
Abstract Plasma-homocystine levels were reduced significantly in three children with homocystinuria through the use of a diet providing only 10 mg. of methionine per kg. body-weight per day, supplemented by L-cystine and large doses of the methyl donor, choline. Pyridoxine had no effect on the biochemical changes in their blood. Reduction of plasma-homocystine may be an important measure for preventing intravascular thromboses in patients who already exhibit the other clinical manifestations of homocystinuria. A 3-year-old child treated for homocystinuria since early infancy with a low-methionine diet and supplemental cystine remains mentally and physically normal, thus suggesting the possibility of preventing all of the ill-effects of the disease by early diagnosis and dietary therapy.