Feb 7, 2020
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Abstract
A synthetic triazene derivative with antineoplastic activity. Upon metabolic activation via N-demethylation, T riN2755 is converted into highly reactive carbocations that can alkylate DNA and other macromolecules, thereby resulting in DNA cross links, inhibiting DNA replication and repair, and subsequently inducing apoptosis. T his agent has high hydrophilicity and photostability and shows a favorable toxicity profile over the other triazenes. Qeios · Definition, February 7, 2020