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These studies suggest that pain after a stroke is common, can be persistent, and significantly affects the quality of life for stroke survivors.
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Pain is a frequent and significant complication following a stroke, affecting a substantial proportion of stroke survivors. Studies indicate that pain occurs in 19-74% of patients post-stroke, with a notable portion experiencing moderate to severe pain . The prevalence of pain tends to decrease over time, but a significant number of patients continue to suffer from persistent pain even after 16 months .
Central post-stroke pain (CPSP) is a direct consequence of the brain lesion caused by the stroke. Although it affects a smaller percentage of stroke patients (1-8%), CPSP is often severe and resistant to treatment, significantly impacting the quality of life . The pain is typically described as burning or sharp and can be continuous or episodic .
Musculoskeletal pain, including shoulder pain and pain related to spasticity, is common among stroke survivors. This type of pain is often associated with physical movements and can lead to chronic suffering and functional loss . Shoulder pain, in particular, is frequently reported and can be exacerbated by conditions such as shoulder subluxation .
Post-stroke headache and complex regional pain syndrome are also prevalent. Headaches can be tension-type and are often triggered by stress and anxiety . Other pain syndromes include joint pain and pain from increased muscle stiffness, which are more common in stroke patients compared to the general population.
Several factors have been identified as predictors of post-stroke pain. Younger age, female sex, higher initial stroke severity (as measured by the NIH stroke scale), and elevated HbA1c levels at stroke onset are significant predictors of pain. Additionally, depression and better cognitive function (as measured by the mini-mental state examination) are associated with higher pain intensity.
Adrenergic antidepressants are the first-line drugs for managing CPSP, although their effectiveness is often incomplete. Antiepileptics like lamotrigine and GABAergic drugs such as gabapentin or pregabalin have shown potential as adjunctive therapies. Despite these options, many patients with central pain receive inadequate pain treatment.
Non-pharmacological treatments, including motor cortex stimulation and deep brain stimulation, have shown promise in certain groups of patients with CPSP. Physical therapy methods, movement therapy, heat and cold therapies, and transcutaneous electrical nerve stimulation (TENS) are effective for managing musculoskeletal pain and pain related to spasticity.
A multidisciplinary approach that combines pharmacological and physical treatments is often necessary to manage post-stroke pain effectively. Early identification of at-risk patients and comprehensive pain assessment are crucial for optimizing treatment and improving the quality of life for stroke survivors .
Pain after stroke is a common and multifaceted issue that significantly affects the quality of life of stroke survivors. Understanding the types, prevalence, and risk factors of post-stroke pain is essential for effective management. A combination of pharmacological and non-pharmacological treatments, along with a multidisciplinary approach, can help mitigate the impact of post-stroke pain and enhance rehabilitation outcomes.
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