CSRD

Introduction

The Carbon Storage Regulator (Csr) system is a global regulatory mechanism in bacteria, particularly in Escherichia coli, that controls gene expression at the post-transcriptional level. This system includes the RNA-binding protein CsrA, noncoding RNAs CsrB and CsrC, and the regulatory protein CsrD, which targets CsrB and CsrC for degradation. The Csr system plays a crucial role in various cellular processes, including metabolism, motility, and stress response.

Key Insights

Role of CsrD in RNA Degradation:
- CsrD targets the noncoding RNAs CsrB and CsrC for degradation by RNase E, thereby regulating the activity of CsrA by controlling the availability of these RNAs .
- The degradation of CsrB/C RNAs by CsrD is crucial for the proper expression of CsrA-controlled genes, linking RNA decay to the availability of preferred carbon sources .
Mechanism of CsrD Action:
- CsrD contains GGDEF and EAL domains, which are typically involved in cyclic di-GMP metabolism, but in this context, they function in RNA degradation without involving cyclic di-GMP .
- The CsrD protein requires HAMP-like, GGDEF, and EAL domains for its activity, while its membrane-spanning regions are dispensable.
CsrA and CsrD Interaction:
- CsrA stabilizes CsrB against RNase E cleavage by binding to specific sites, while CsrD overcomes this protection, facilitating RNA degradation.
- The interaction between CsrA and CsrD provides a regulatory mechanism that links RNA stability to environmental conditions, such as the presence of a preferred carbon source.
Conservation Across Species:
- The Csr system, including CsrA, CsrB, CsrC, and CsrD, is conserved across various bacterial species, such as Serratia marcescens, indicating its fundamental role in bacterial physiology.

Conclusion

The Csr system in bacteria, particularly the role of CsrD, is essential for regulating gene expression by controlling the degradation of noncoding RNAs CsrB and CsrC. CsrD facilitates the decay of these RNAs by RNase E, thereby modulating the activity of CsrA. This regulatory mechanism is conserved across different bacterial species, highlighting its importance in bacterial adaptation and response to environmental changes.

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Identification of a novel regulatory protein (CsrD) that targets the global regulatory RNAs CsrB and CsrC for degradation by RNase E.

CsrD protein selectively targets global regulatory RNAs CsrB and CsrC for degradation by RNase E, affecting gene expression and demonstrating a novel function for a GGDEF-EAL protein.

Antagonistic control of the turnover pathway for the global regulatory sRNA CsrB by the CsrA and CsrD proteins

The CsrD-RNase E pathway plays a crucial role in regulating bacterial gene expression by decoupling Csr sRNA decay from CsrA binding and connecting it to the availability of a preferred carbon source.

CSRDB: a small RNA integrated database and browser resource for cereals

The Cereal Small RNA Database (CSRDB) provides a bioinformatics resource for cereal crops, containing large-scale datasets of maize and rice small RNA sequences and enabling data linking and integration.

Post-transcriptional regulation on a global scale: form and function of Csr/Rsm systems.

CsrA (RsmA) plays a crucial role in regulating various eubacterial metabolic pathways, biofilm formation, motility, and virulence circuitry, with new mechanisms of gene activation and repression emerging.

CsrA Inhibits Translation Initiation of Escherichia coli hfq by Binding to a Single Site Overlapping the Shine-Dalgarno Sequence

CsrA in Escherichia coli inhibits hfq gene translation by binding to a single site overlapping the Shine-Dalgarno sequence, preventing ribosome binding and contributing to mRNA destabilization.

The Role of CSRD on Company's Financial Performance and Earnings Response Coefficient (ERC)

CSRD influences ROE but does not influence ROA and ERC, as investors tend to focus on short-term information rather than middle and long-term information.

PENGARUH CORPORATE SOCIAL RESPONSIBILITY DISCLOSURE (CSRD) TERHADAP RASIO PROFITABILITAS DAN EARNING RESPONSE COEFFICIENT (ERC)

Corporate Social Responsibility Disclosure (CSRD) significantly improves Return on Asset and Return on Equity in manufacturing firms, but does not affect Net Profit Margin or Earning Response Coefficient (ERC).

Identification of a Csr system in Serratia marcescens 2170.

The carbon storage regulator (Csr) system in Serratia marcescens 2170 consists of an RNA-binding protein, two Csr small RNAs, and a decay factor for Csr small RNAs, complementing the E. coli Csr system.

Multi-dimensional resource defragmentation (MDRD) based on cluster SDON controller (CSC) paradigm in spatial division multiplexing enabled elastic optical networks (SDM-EON)

Cluster control technology effectively reorganizes spectral and spatial resources in elastic optical networks, improving performance and efficiency.

Regulation of CsrB/C sRNA decay by EIIAGlc of the phosphoenolpyruvate: carbohydrate phosphotransferase system

EIIAGlc plays a crucial role in regulating CsrB/C sRNA decay, affecting global regulatory circuitry in response to nutritional status.

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