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Diarrhea, Headache, and Fatigue: Common Symptoms Across Various Conditions

Diarrhea in COVID-19 and Other Infections

Diarrhea is a notable symptom in several infectious diseases, including COVID-19 and cryptosporidiosis. In COVID-19 patients, diarrhea has been observed as an initial symptom and is associated with a higher risk of severe disease progression 158. Similarly, cryptosporidiosis, a parasitic infection, often leads to chronic diarrhea, which can persist for months after the initial infection . This symptom is particularly concerning in immunocompromised individuals, where it can lead to severe complications .

Headache: A Common Neurological Symptom

Headaches are frequently reported in patients with COVID-19 and other conditions. In COVID-19, headaches are among the less common symptoms but still affect a significant portion of patients 34710. The presence of headaches in COVID-19 patients has been linked to higher levels of inflammatory markers such as IL-6, indicating a possible inflammatory response . Additionally, headaches are a common long-term sequelae in patients recovering from cryptosporidiosis, highlighting the persistent nature of this symptom across different infections .

Fatigue: A Pervasive Symptom

Fatigue is a prevalent symptom in many diseases, including COVID-19 and cryptosporidiosis. In COVID-19, fatigue is one of the most common symptoms, affecting over a third of patients 1347. This symptom can be debilitating and is often associated with other symptoms such as myalgia and dyspnea 13. Similarly, fatigue is a long-term consequence of cryptosporidiosis, affecting nearly a quarter of patients long after the initial infection has resolved . This persistent fatigue can significantly impact the quality of life and daily functioning of affected individuals.

Conclusion

Diarrhea, headache, and fatigue are common symptoms that span across various infectious diseases, including COVID-19 and cryptosporidiosis. These symptoms not only present during the acute phase of the illness but can also persist as long-term sequelae, affecting patients' quality of life. Understanding the prevalence and impact of these symptoms can aid in better management and treatment strategies for affected individuals.

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Most relevant research papers on this topic

Clinical Symptom Differences Between Mild and Severe COVID-19 Patients in China: A Meta-Analysis

COVID-19 patients with initial symptoms of dyspnea, hemoptysis, anorexia, diarrhea, or fatigue, especially abdominal pain, should be closely monitored for disease deterioration.

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76citations

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Health sequelae of human cryptosporidiosis in industrialised countries: a systematic review

Long-term sequelae of cryptosporidiosis in industrialized countries include chronic diarrhoea, weight loss, and various other health issues.

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2020·

30citations

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COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis

COVID-19 patients have a higher discharge rate (52%), with a fatality rate of 5%, and the main clinical symptoms are fever, cough, myalgia, fatigue, expectoration, and dyspnea.

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·Long-Quan Li et al.

Sore throat in COVID‐19: Comment on “Clinical characteristics of hospitalized patients with SARS‐CoV‐2 infection: A single arm meta‐analysis”

COVID-19 patients often experience fever, cough, muscle soreness, and fatigue, but rarely experience diarrhea, hemoptysis, headache, sore throat, shock, and other rare symptoms.

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2020·

35citations

·A. Lovato et al.

SARS-CoV-2 induced diarrhoea as onset symptom in patient with COVID-19

COVID-19 patients with gastrointestinal symptoms should be evaluated for virus infectivity, especially during the outbreak period.

Case ReportRigorous JournalHighly Cited

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Case records of the Massachusetts General Hospital. Case 7-2014. A 27-year-old man with diarrhea, fatigue, and eosinophilia.

A 27-year-old man with diarrhea, fatigue, and eosinophilia was admitted to the hospital with a history of ulcerative colitis and no known allergies.

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2014·

7citations

·A. Fathi et al.

Vascular skin symptoms in COVID‐19: a French observational study

COVID-19 patients may experience vascular skin symptoms, such as erythematous rash, urticaria, and chicken pox-like lesions, which may be linked to ACE2 deficiency.

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·J. Bouaziz et al.

The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19

COVID-19 patients with gastrointestinal symptoms should receive prompt treatment adjustments, considering intestinal immune damage and drug-induced diarrhea, to prevent secondary bacterial infections and maintain intestinal balance.

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·Q. Ye et al.

Celiac Disease Symptom Resolution: Effectiveness of the Gluten-free Diet

A strict gluten-free diet can effectively resolve gastrointestinal and extra-intestinal symptoms in children with celiac disease, with greater improvements in gastrointestinal symptoms than extra-intestinal symptoms.

Highly Cited

2018·

79citations

·N. Sansotta et al.

A prospective clinical study of detailed neurological manifestations in patients with COVID-19

Neurological symptoms, particularly headache, are common in COVID-19 patients, and identifying these symptoms can help prevent diagnosis delays and virus spread.

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2020·

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·Ö. Karadaş et al.

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