Does metformin cause hair loss
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Metformin and Hair Loss: Analyzing the Evidence
Introduction to Metformin and Its Uses
Metformin is a widely used oral medication primarily prescribed for managing type 2 diabetes mellitus. It is known for its efficacy in glycemic control and its antioxidant properties, which have led researchers to explore its potential benefits in various other medical conditions.
Metformin and Hair Regrowth
Central Centrifugal Cicatricial Alopecia (CCCA)
One study highlights the potential of metformin in promoting hair regrowth in patients with Central Centrifugal Cicatricial Alopecia (CCCA), a progressive scarring alopecia predominantly affecting women of African descent. The study presented two cases where topical application of metformin resulted in significant hair regrowth. This suggests that metformin may have a beneficial role in treating certain types of hair loss, particularly those associated with fibrosis.
Metformin and Hair Cell Protection
Gentamicin-Induced Hair Cell Death
Another study investigated the protective effects of metformin against gentamicin-induced hair cell death. In vitro experiments showed that metformin could block the translocation of endonuclease G into the nucleus of outer hair cells, thereby attenuating hair cell loss. However, in vivo studies did not support these findings, as metformin did not prevent gentamicin-induced ototoxicity and, in some cases, exacerbated the condition.
Conclusion
The current evidence does not support the notion that metformin causes hair loss. On the contrary, metformin has shown potential benefits in promoting hair regrowth in specific conditions like CCCA and protecting hair cells in vitro. However, more research is needed to fully understand its effects and potential applications in hair loss treatments.
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