Lisinopril cough
Searched over 200M research papers for "lisinopril cough"
Summary
10 papers analyzed
These studies suggest that lisinopril is associated with a higher incidence of cough compared to alternatives like losartan, telmisartan, and valsartan, which have significantly lower rates of cough-related side effects.
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Lisinopril-Induced Cough: Incidence, Gender Differences, and Comparisons with Other Antihypertensive Agents
Introduction to Lisinopril-Induced Cough
Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is widely used for treating hypertension. However, a common side effect associated with ACE inhibitors, including lisinopril, is a persistent dry cough. This article synthesizes research findings on the incidence of lisinopril-induced cough, gender differences in its occurrence, and comparisons with other antihypertensive agents.
Incidence of Lisinopril-Induced Cough
Several studies have documented the high incidence of cough in patients treated with lisinopril. In a study comparing lisinopril with losartan and hydrochlorothiazide, 72% of patients on lisinopril reported experiencing a cough, significantly higher than those on losartan (29%) or hydrochlorothiazide (34%) . Another study found that 60% of patients on lisinopril experienced a cough, compared to 15.6% on telmisartan and 9.7% on placebo. These findings consistently indicate that lisinopril is associated with a higher incidence of cough compared to other antihypertensive agents.
Gender Differences in Lisinopril-Induced Cough
Research has also highlighted a gender disparity in the occurrence of lisinopril-induced cough. Women are more likely to report this side effect than men. In one study, 12.6% of women treated with lisinopril reported a cough, compared to only 4.4% of men. This suggests that female patients may be more susceptible to developing a cough when treated with lisinopril.
Comparisons with Other Antihypertensive Agents
Losartan and Telmisartan
Losartan and telmisartan, both angiotensin II receptor antagonists, have been shown to cause significantly fewer instances of cough compared to lisinopril. Studies have demonstrated that the incidence of cough with losartan is much lower, ranging from 18% to 36.7%, compared to 68.9% to 87.5% with lisinopril . Similarly, telmisartan has been associated with a lower incidence of cough (15.6%) compared to lisinopril (60%).
Hydrochlorothiazide and Metolazone
Hydrochlorothiazide, a diuretic, and metolazone, another diuretic, have also been compared with lisinopril. The incidence of cough with hydrochlorothiazide was found to be significantly lower (19.0% to 34%) than with lisinopril (68.9% to 72%) . Metolazone showed a similar trend, with only 21% of patients reporting a cough compared to 97% with lisinopril.
Conclusion
Lisinopril-induced cough is a common and significant side effect, particularly prevalent among female patients. Comparisons with other antihypertensive agents such as losartan, telmisartan, hydrochlorothiazide, and metolazone consistently show that these alternatives are associated with a much lower incidence of cough. For patients who develop a cough with lisinopril, switching to an angiotensin II receptor antagonist or a diuretic may be a viable option to mitigate this side effect.
Sources and full results
Most relevant research papers on this topic
6
Lisinopril cough.
6
3 Citations
1986
8
ACE inhibitors, angiotensin II antagonists and cough
8
23 Citations
1995
9
Modulation of the renin-angiotensin-aldosterone system and cough.
9
18 Citations
1995