Mood enhancers
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Mood Enhancers: A Comprehensive Overview
Internet-Based Guided Self-Help for Depression
GET.ON Mood Enhancer Efficacy
The GET.ON Mood Enhancer is an Internet-based guided self-help intervention designed to alleviate symptoms of major depressive disorder (MDD). A randomized controlled trial (RCT) compared its efficacy to online psychoeducation for depression (OPD). The study involved 128 adults with MDD, who were assessed for depressive symptoms, anxiety, and quality of life at baseline, 6 weeks, and 12 weeks post-randomization. Results indicated that the GET.ON Mood Enhancer significantly reduced depressive symptoms compared to OPD, highlighting the potential of Internet-based interventions in managing depression .
Pharmacological Mood Enhancement
Off-Label Use of Psychopharmacological Agents
Certain drugs, originally developed for neuropsychiatric disorders, have shown potential in enhancing mood and cognitive functions. However, the long-term effects of these enhancements remain uncertain and could be harmful. Therefore, while competent individuals may choose to use these agents, they must be aware of the associated risks and take responsibility for their use .
Neurotransmitter Systems and Mood Enhancement
Recent advancements in neuroscience and psychopharmacology have expanded the possibilities for pharmacological enhancement of mood. Drugs acting on various neurotransmitter systems can enhance mood and pro-social behavior. However, these drugs can have complex effects, such as dose-dependent variations and potential trade-offs between cognitive stability and flexibility .
Curcumin and Mood Function
Curcumin, a compound with neurogenic, anti-inflammatory, and antioxidant properties, has been shown to improve mood and cognitive function in a rat model of Gulf War Illness (GWI). Curcumin treatment led to enhanced neurogenesis, reduced inflammation, and normalized mitochondrial function, suggesting its potential as a mood enhancer .
Endocannabinoids in Mood Disorders
Cannabinoid agonists and endocannabinoid enhancers, such as FAAH inhibitors, have demonstrated antidepressant potential in preclinical studies. These agents increase serotonin and noradrenergic neuronal activity, promote neurogenesis, and may offer an alternative to traditional antidepressants for mood disorders .
Non-Pharmacological Mood Enhancement
Exercise and Massage
Physical activities like running and massage therapy have been shown to consistently produce positive mood enhancements. A study involving students in various physical education classes found that both running and massage significantly improved mood states compared to a control rest condition .
Tryptophan-Rich Dietary Supplements
A tryptophan-rich protein hydrolysate supplement has been found to improve emotional processing, mental energy levels, and reaction times in middle-aged women. This supplement, derived from egg protein, shifts emotional bias away from negative stimuli and enhances overall mood and cognitive functions .
Public and Professional Attitudes
Acceptance of Mood Enhancers
A study on attitudes towards mood enhancement among the general public and general practitioners (GPs) revealed a preference for natural remedies over pharmaceuticals. While natural remedies were fairly acceptable, the use of pharmaceuticals for mood enhancement in healthy individuals was generally viewed negatively. Altruistic reasons for enhancement were more acceptable than egoistic ones .
Conclusion
Mood enhancers encompass a wide range of interventions, from Internet-based self-help programs and pharmacological agents to non-pharmacological methods like exercise and dietary supplements. While each approach has its benefits, it is crucial to consider the potential risks and ethical implications associated with their use. As research continues to evolve, a balanced and informed perspective on mood enhancement will be essential for both individuals and healthcare providers.
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