How much Spermidine should I take daily?
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Daily Spermidine Supplementation: Recommended Dosage and Safety
Introduction to Spermidine Supplementation
Spermidine is a naturally occurring polyamine that plays a significant role in cellular metabolism and has been linked to various health benefits, including the potential to delay age-related diseases. As spermidine levels decline with age, supplementation has been proposed as a preventive measure.
Recommended Dosage of Spermidine
Current research on the optimal dosage of spermidine supplementation is still evolving. A study investigating the pharmacokinetics of spermidine supplementation administered 15 mg per day to healthy adults. The results indicated that this dosage significantly increased spermine levels in the plasma but did not affect spermidine or putrescine levels in the blood or saliva. This suggests that spermidine is converted into spermine, which then circulates in the bloodstream.
Another study focused on the safety and tolerability of spermidine supplementation in older adults with subjective cognitive decline. In this study, participants were given a spermidine-rich plant extract at a dosage of 1.2 mg per day for three months. The results showed no adverse effects, indicating that this lower dosage is safe and well-tolerated.
Safety and Tolerability
The safety profile of spermidine supplementation has been evaluated in both animal and human studies. In a preclinical study, mice were given spermidine for 28 days, and no morbidities or behavioral changes were observed. Post-mortem examinations also showed no increase in tumorigenic or fibrotic events.
In a human trial involving older adults, a 1.2 mg daily dosage of spermidine was found to be safe over a three-month period. No significant differences were observed between the spermidine and placebo groups in terms of vital signs, weight, clinical chemistry, hematological parameters, or self-reported health status. Compliance rates were above 85%, indicating excellent tolerability.
Conclusion
Based on current research, a daily dosage of 1.2 mg of spermidine appears to be safe and well-tolerated in older adults. Higher doses, such as 15 mg per day, have been shown to affect plasma spermine levels but require further investigation to confirm their long-term safety and efficacy. As always, it is advisable to consult with a healthcare provider before starting any new supplementation regimen.
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Most relevant research papers on this topic
High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
The Effect of Spermidine Supplementation on Cognitive Function in Adults: A Mini-Review
Spermine and spermidine induce intestinal maturation in the rat.
Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters
Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline
P57. Safety and tolerability of spermidine supplementation: A translational study in mice and older adults with subjective cognitive decline
Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice
Spermidine Ameliorates Nonalcoholic Steatohepatitis through Thyroid Hormone-Responsive Protein Signaling and the Gut Microbiota-Mediated Metabolism of Bile Acids.
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