psoriasis

Introduction

Psoriasis is a chronic, immune-mediated inflammatory disorder that primarily affects the skin but can also involve the nails and joints. It is characterized by erythematous, scaling patches and plaques, and can significantly impact the quality of life of those affected. Recent research has provided deeper insights into its pathogenesis, comorbidities, and treatment options.

Key Insights

Immune-Mediated Pathogenesis:
- Psoriasis is driven by proinflammatory cytokines, with key roles played by dendritic cells, T-cells, and cytokines such as IL-17, IL-23, and TNFα .
- Genetic factors, including the HLA-C*06:02 allele, and environmental triggers like infections, stress, and lifestyle factors, contribute to disease onset and progression .
Clinical Manifestations:
- Psoriasis presents in various forms, with chronic plaque psoriasis (psoriasis vulgaris) being the most common, accounting for 90% of cases .
- Other forms include pustular and erythrodermic psoriasis, and it can also affect the nails and joints, leading to psoriatic arthritis .
Comorbidities:
- Psoriasis is associated with several comorbid conditions, including psoriatic arthritis, cardiovascular disease, diabetes, obesity, inflammatory bowel disease, and depression .
- Chronic inflammation is believed to be a common underlying factor linking psoriasis with these comorbidities .
Impact on Quality of Life:
- The visible nature of psoriasis can lead to significant psychosocial and emotional distress, affecting personal and professional lives .
- Depression and impaired quality of life are common among psoriasis patients .
Advances in Treatment:
- Understanding the immunological basis of psoriasis has led to the development of targeted biological therapies that inhibit specific cytokines like IL-17, IL-23, and TNFα, revolutionizing the treatment of severe cases .
- Early diagnosis and comprehensive management, including lifestyle modifications and personalized treatment approaches, are crucial for minimizing physical and psychological harm .

Conclusion

Psoriasis is a complex, chronic inflammatory disease with significant genetic and environmental components. It manifests primarily as chronic plaque psoriasis but can take various forms and is associated with multiple comorbidities. Advances in understanding its immunological underpinnings have led to effective targeted therapies, improving patient outcomes. Comprehensive management strategies are essential to address both the physical and psychosocial impacts of the disease.

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Psoriasis

Psoriasis is an immune-mediated cutaneous disorder characterized by chronic, scaling, erythematous patches and plaques of skin, often involving the nails and affecting personal and working lives.

Management of psoriasis as a systemic disease: what is the evidence?

Psoriasis is a chronic, systemic disease with increased risk of comorbidities, and effective management requires addressing its systemic nature and addressing its impact on overall health.

Psoriasis

Psoriasis is a complex, immune-mediated disease with high prevalence, chronicity, disfiguration, disability, and associated comorbidities, requiring early diagnosis and comprehensive management.

Pathogenesis and clinical features of psoriasis

Psoriasis is a complex immune-mediated skin disease with various clinical phenotypes and comorbidities, and understanding its pathomechanisms is leading to new treatments.

Psoriasis

Psoriasis management aims to minimize physical and psychological harm by treating early, preventing multimorbidity, implementing lifestyle modifications, and implementing a personalised approach to treatment.

Comorbidities in psoriasis

Psoriasis is associated with various comorbidities, including arthritis, Crohn's disease, and increased risk of cardiovascular disease, and early anti-inflammatory treatment may be preventive.

Psoriasis and comorbid diseases: Epidemiology.

Psoriasis is associated with various comorbid diseases, including psoriatic arthritis, cardiometabolic diseases, gastrointestinal diseases, kidney disease, malignancy, infection, and mood disorders.

Psoriasis: from pathogenesis to novel therapeutic approaches.

Understanding the immunology of psoriatic plaques has led to new therapeutic options and immunomodulation approaches, improving psoriasis management.

Psoriasis: epidemiology, clinical features, and quality of life

Psoriasis is a common chronic skin and joint disease with a strong genetic component and environmental factors playing a role in its presentation.

Pathogenesis and therapy of psoriasis

Psoriasis is a common skin disease caused by excessive growth and aberrant differentiation of keratinocytes, with new therapies targeting immune components and potentially predicting treatments for other inflammatory human diseases.

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