What are the most common side effects of nortriptyline
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Common Side Effects of Nortriptyline
Nortriptyline, a tricyclic antidepressant, is widely used for treating depression and neuropathic pain. However, like many medications, it comes with a range of side effects. This article synthesizes findings from multiple studies to highlight the most common side effects associated with nortriptyline.
Dry Mouth and Increased Perspiration
One of the most frequently reported side effects of nortriptyline is dry mouth. Studies have consistently shown a strong correlation between nortriptyline plasma levels and the incidence of dry mouth 1245. Increased perspiration is another common side effect that has been observed in patients undergoing treatment with nortriptyline .
Constipation and Weight Gain
Constipation is another notable side effect, affecting approximately one-third of patients on nortriptyline . Weight gain, although less common, has also been reported in some patients .
Cardiovascular Effects: Increased Heart Rate and Orthostatic Hypotension
Nortriptyline has been associated with cardiovascular side effects, including an increased heart rate. This effect has been consistently observed in patients undergoing long-term treatment . Additionally, nortriptyline can cause orthostatic hypotension, a condition where blood pressure drops significantly upon standing, although this effect is not more pronounced in geriatric patients compared to younger ones .
Sleep Disturbances and Physical Tiredness
Sleep disturbances, including daytime sleepiness and nocturnal sleep disruption, have been reported in patients treated with nortriptyline. These symptoms are often related to residual depression rather than the medication itself 23. Physical tiredness is another side effect that has been noted, although it is also frequently linked to the underlying depressive condition 23.
Rare Side Effects: Seborrheic Dermatitis
While rare, some patients may experience seborrheic dermatitis as a side effect of nortriptyline. This skin condition was observed in a case study where the patient developed lesions that resolved upon discontinuation of the drug .
Conclusion
Nortriptyline is an effective medication for treating depression and neuropathic pain, but it comes with a range of side effects. The most common include dry mouth, increased perspiration, constipation, weight gain, increased heart rate, orthostatic hypotension, sleep disturbances, and physical tiredness. Rarely, it can cause seborrheic dermatitis. Understanding these side effects can help in managing them effectively and improving patient adherence to the treatment.
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