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These studies suggest that autophagy promotes health and longevity by removing damaged cellular content, regulating stress responses, and recycling macromolecules and organelles, thereby reducing cellular damage and age-related diseases.
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Autophagy is a conserved cellular process that degrades and recycles damaged cellular components, playing a crucial role in maintaining cellular homeostasis. Recent research has highlighted its significant role in promoting health and longevity by mitigating cellular damage and supporting metabolic fitness.
Cellular Damage Mitigation:
Regulation by Longevity Pathways:
Tissue-Specific Benefits:
Selective Autophagy:
Pharmacological Interventions:
Non-Cell Autonomous Effects:
Autophagy promotes health and longevity by mitigating cellular damage, being regulated by key longevity pathways, and providing tissue-specific and systemic benefits. Pharmacological induction of autophagy presents a promising avenue for extending lifespan. Understanding these mechanisms further could lead to novel strategies for enhancing human healthspan.
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