Huang Wei-yi
2006
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Twelve substituted 1-indanones(Ⅰa~Ⅰl) were prepared either by the cyclization reaction of substituted 3-phenylpropanoic acid in the presence of polyphosphoric acid,or from the corresponding acid chloride in the presence of aluminum chloride.2-bromo-1-indanones(Ⅱa~Ⅱl,Ⅱf,Ⅱj,(Ⅱk) and Ⅱl were novel compounds) in yields of 67.2%~91.5% were synthesized by the bromination reaction of Ⅰ using copper(Ⅱ) bromide as a bromination regent.The reaction conditions were as follows: Ⅰ 10 mmol was dissolved in 20 mL ethyl acetate and 20 mL chloroform,copper(Ⅱ) bromide was added by three times(60%,24% and 16% each) under reflux.The structures of the novel compounds were confirmed by ~1H NMR.