1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity.

doi:10.1021/JM00394A040

Paper

1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity.

Published Nov 1, 1987 · K. Shyam, R. T. Hrubiec, R. Furubayashi

Journal of medicinal chemistry

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29

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0

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Abstract

A series of 1,2-bis(sulfonyl)hydrazines was synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. The most active agent to emerge from this study, 1,2-bis(methylsulfonyl)-1-methylhydrazine, produced a maximum % T/C for mice bearing the L1210 leukemia or the B16 melanoma of 340% and 278%, respectively. Two N-chloroethyl analogues, conceived as bifunctional alkylating agents, were also synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. Although such a modification resulted in retention of antineoplastic activity against both tumor cell lines, it did not result in enhanced antineoplastic activity.

In Vitro Study

Study Snapshot

1,2-bis(methylsulfonyl)-1-methylhydrazine shows the most antineoplastic activity against L1210 leukemia and B16 melanoma, with retention of activity but not enhanced activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity.

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References

Citations

A green and novel method for synthesis of β-sulfonyl esters under solvent-free conditions

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