1,2-Dichloroethane

doi:10.1007/978-1-4612-3922-2_6

Paper

1,2-Dichloroethane

Published 1988 · George W. Ware

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Abstract

The major use of 1,2-dichloroethane, also known as ethylene dichloride, EDC, and 1,2-EDC, is in the production of vinyl chloride (USEPA 1985a). In addition, it is used as a starting material for the production of other solvents and as a lead scavenging additive in gasolines. 1,2-Dichloroethane is widely exported by the US. Some of its minor uses are as a solvent in metal degreasing and textile and polyvinyl chloride cleaning; in paints, coatings, and adhesives; as a grain fumigant; as a varnish and finish remover; in soaps and scouring compounds; as a wetting and penetrating agent; in ore flotation; and as a chemical intermediate. Its structure and properties are shown in Table 1.

Study Snapshot

1,2-Dichloroethane is a key component in the production of vinyl chloride and various solvents, as well as a lead scavenging additive in gasolines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

1,2-Dichloroethane

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References

Metabolism of Chloroacetate‐1‐14C in the Mouse

Chloroacetic acid in mice is mainly eliminated as urine, with 82-88% found in the urine and feces, and its major metabolites are S-carboxymethyl-L-cysteine and thiodiacetic acid.

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The metabolism of 1,2-dichloroethane in mice mainly involves chloroacetic acid, with minor amounts of 2-chloroethanol and S-(-hydroxyethyl)-cysteine.

Odor as an ald to chemical safety: Odor thresholds compared with threshold limit values and volatilities for 214 industrial chemicals in air and water dilution

This paper provides data on odor thresholds for 214 industrial chemicals, enabling estimation of detectability, warning potential, and rousing capacity, aiding in industrial health and safety.

Effects of 1,2-dichloroethane and 1,1,1-trichloroethane in drinking water on reproduction and development in mice*1

1,2-dichloroethane and 1,1,1-trichloroethane in drinking water did not produce significant dominant lethal mutations or terata in mice, with no dose-dependent effects on fertility, gestation, viability, or lactation indices.

Design of aeration towers to strip volatile contaminants from drinking water

Air stripping in packed towers may be a cost-effective method for removing volatile organic contaminants from drinking water, with a design methodology that considers water and air temperature, contaminant volatility, and packing type and size.

The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium. II. Activation by the isolated perfused rat liver.

1,2-dichloroethane and 1,2-dibromoethane activate Salmonella typhimurium through conjugation with glutathione, producing mutagenic bile in the liver, while 2-chloroethanol does not.

Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide.

Chloroacetaldehyde is a highly mutagenic metabolite of 1,2-dichloroethane, vinyl chloride, and cyclophosphamide, but it is not the active mutagenic form of cyclophosphamide.

The mutagenicity and DNA-modifying effect of haloalkanes.

Haloalkanes are mutagenic for Salmonella typhimurium and preferentially inhibit the growth of DNA polymerase-deficient Escherichia coli, suggesting their use in routine environmental screening.

Citations

Application of Dehalogenase Enzymes in Bioremediation of Halogenated Pollutants

Dehalogenase enzymes in microorganisms can effectively convert toxic halogenated hydrocarbons into non-toxic forms, aiding in bioremediation of 1,2 dichloroethane.