13-cis-retinoic acid stimulates in vitro mannose 6-phosphate hydrolysis and inhibits retinol esterification and benzo[a]pyrene hydroxylation by rat-liver microsomes.

doi:10.1016/0005-2760(88)90139-7

Paper

13-cis-retinoic acid stimulates in vitro mannose 6-phosphate hydrolysis and inhibits retinol esterification and benzo[a]pyrene hydroxylation by rat-liver microsomes.

Published Jul 1, 1988 · M. D. Ball, J. Olson

Biochimica et biophysica acta

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Abstract

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In Vitro Study

Study Snapshot

13-cis-retinoic acid increases permeability of rat-liver microsomal membranes to mannose 6-phosphate and inhibits retinol esterification and benzo[a]pyrene hydroxylation in vitro, potentially impacting both its therapeutic and toxic effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

13-cis-retinoic acid stimulates in vitro mannose 6-phosphate hydrolysis and inhibits retinol esterification and benzo[a]pyrene hydroxylation by rat-liver microsomes.

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References

Citations

The influence of dietary vitamin A intake on microsomal membrane fluidity and lipid composition

Dietary vitamin A intake affects rat liver microsome fluidity and lipid composition, with deficiency leading to lower phospholipid/cholesterol ratio and hypervitaminosis leading to higher saturated/unsaturated fatty acid ratio and lower phosphatidylcholine/sphingo

Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor beta production.

Retinoic acid effectively inhibits liver cell proliferation and reduces collagen and transforming growth factor beta production, potentially reducing hepatic fibrogenesis.

Modulation of vitamin A metabolism during hepatic and intestinal cell culture.

Vitamin A storage is affected by changes in the surrounding extracellular matrix and soluble cytokine mediators, with hepatic cells showing reduced retinyl esterification on type I collagen in the presence of TGF.