1,4-Diazepines: A Review on Synthesis, Reactions and Biological Significance.

doi:10.2174/1570179416666190703113807

Paper

1,4-Diazepines: A Review on Synthesis, Reactions and Biological Significance.

Published Jul 31, 2019 · M. Rashid, A. Ashraf, Sahibzada Shakir Rehman

Current organic synthesis

Q3 SJR score

19

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0

Influential Citations

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Abstract

BACKGROUND 1,4-Diazepines are two nitrogen containing seven membered heterocyclic compounds and associated with a wide range of biological activities. Due to its medicinal importance, scientists are actively involved in the synthesis, reactions and biological evaluation of 1,4-diazepines since number of decades. OBJECTIVE The primary purpose of this review is to discuss the synthetic schemes and reactivity of 1,4- diazepines. This article also describes biological aspects of 1,4-diazepine derivatives, that can be usefully exploited for the pharmaceutical sector. CONCLUSION This review summarizes the abundant literature on synthetic routes, chemical reactions and biological attributes of 1,4-diazepine derivatives. We concluded that 1,4-diazepines have significant importance due to their biological activities like antipsychotic, anxiolytic, anthelmintic, anticonvulsant, antibacterial, antifungal and anticancer. 1,4-diazepine derivatives with significant biological activities could be explored for potential use in the pharmaceutical industries.

Literature Review

Study Snapshot

1,4-diazepines have significant biological activities, including antipsychotic, anxiolytic, anthelmintic, anticonvulsant, antibacterial, antifungal, and anticancer properties, making them potentially useful in pharmaceutical industries.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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1,4-Diazepines: A Review on Synthesis, Reactions and Biological Significance.

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References

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Citations

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