1,4-Dichlorobenzene-Induced Liver Tumors in the Mouse: Evaluation of the Role of Chlorohydroquinones

doi:10.1515/REVEH.2002.17.4.279

Paper

1,4-Dichlorobenzene-Induced Liver Tumors in the Mouse: Evaluation of the Role of Chlorohydroquinones

Published 2002 · M. Muller,

Reviews on Environmental Health

Q2 SJR score

6

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1

Influential Citations

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Abstract

1,4-Dichlorobenzene (1,4-DCB) is a wide-spread environmental contaminant and well-described hepatotoxicant for rats and mice. The prolonged oral or inhalation exposure to 1,4-DCB is associated with an increased frequency of hepatic tumors in mice, but not in rats. Evidence is lacking of direct genotoxicity with 1,4-DCB or its metabolites, and no generally accepted mechanism has been found to account for the increased numbers of 1,4-DCB-induced hepatic tumors in mice. No information is available on the carcinogenic effects of 1,4-DCB in humans. Here we consider evidence that the biotransformation of 1,4-DCB to substituted hydroquinone species contributes to hepatic adenoma and carcinoma formation in mouse liver. This phenomenon has implications for human carcinogenesis.

Study Snapshot

1,4-dichlorobenzene biotransformation to substituted hydroquinone species contributes to hepatic tumor formation in mice, potentially impacting human carcinogenesis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

1,4-Dichlorobenzene-Induced Liver Tumors in the Mouse: Evaluation of the Role of Chlorohydroquinones

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Citations

Association between volatile organic compounds exposure and periodontitis: A representative cross-sectional study.

Exposure to 1,4-dichlorobenzene is associated with a 16% increased risk of periodontitis, with total bilirubin levels mediating this association.

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DNA polymerase beta plays a role in protecting human bronchial epithelial cells from damage caused by hydroquinone, suggesting its potential role in preventing lung cancer.